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Antimicrobial Agents and Chemotherapy, March 2001, p. 949-951, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.949-951.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of Efficacies of Cysteine Protease Inhibitors against Five Strains of Plasmodium falciparum

Ajay Singh and Philip J. Rosenthal*

Department of Medicine, San Francisco General Hospital and University of California, San Francisco, California

Received 17 July 2000/Returned for modification 2 October 2000/Accepted 15 December 2000

Falcipain-2, a cysteine protease and essential hemoglobinase of Plasmodium falciparum, is a potential antimalarial drug target. We compared the falcipain-2 sequences and sensitivities to cysteine protease inhibitors of five parasite strains that differ markedly in sensitivity to established antimalarial drugs. The sequence of falcipain-2 was highly conserved, and the sensitivities of all of the strains to falcipain-2 inhibitors were very similar. Thus, cross-resistance between cysteine protease inhibitors and other antimalarial agents is not expected in parasites that are now circulating and falcipain-2 remains a promising chemotherapeutic target.

* Corresponding author. Mailing address: Department of Medicine, Box 0811, University of California, San Francisco, CA 94143-0811. Phone: (415) 206-8845. Fax: (415) 648-8425. E-mail: rosnthl{at}itsa.ucsf.edu.

Antimicrobial Agents and Chemotherapy, March 2001, p. 949-951, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.949-951.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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