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Antimicrobial Agents and Chemotherapy, March 2001, p. 959-961, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.959-961.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Uptake of SCH 27899 (Evernimicin) by Rat Alveolar Macrophages

Shmuel Zbaida,1,* Joan Brieland,2,* Philip Krieter,1 David Loebenberg,2 Gopal Krishna,1 Debra Horne,1 Xiaowen Lu,1 Yuan Yuan,1 Roberta Hare,2 Mitchell N. Cayen,1 and James E. Patrick1

Departments of Drug Metabolism and Pharmacokinetics1 and Chemotherapy and Molecular Genetics,2 Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300

Received 18 May 2000/Returned for modification 14 October 2000/Accepted 26 December 2000

The in vitro uptake of [14C]evernimicin ([14C]SCH 27899) by primary cultures of rat alveolar macrophages and hepatocytes was determined. Both cell populations exhibited linear rates of uptake. However, the initial rate of drug uptake by alveolar macrophages was about threefold higher than that by hepatocytes. These findings demonstrate that [14C]evernimicin is taken up by rat alveolar macrophages, supporting the likelihood that the drug is able to reach sites of infection.

* Corresponding author. Mailing address for Shmuel Zbaida: Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033-1300. Phone: (908) 740-3208. Fax: (908) 740-3966. E-mail: shmuel.zbaida{at}spcorp.com. Mailing address for Joan Brieland: Department of Chemotherapy and Molecular Genetics, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033-1300. Phone: (908) 740-3147. Fax: (908) 740-3918. E-mail: joan.brieland{at}spcorp.com.

Antimicrobial Agents and Chemotherapy, March 2001, p. 959-961, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.959-961.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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