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Antimicrobial Agents and Chemotherapy, April 2001, p. 1284-1286, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1284-1286.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Hypersusceptibility of the Pseudomonas aeruginosa nfxB Mutant to beta -Lactams Due to Reduced Expression of the AmpC beta -Lactamase

Nobuhisa Masuda,*,1 Eiko Sakagawa,1 Satoshi Ohya,1 Naomasa Gotoh,2 and Takeshi Nishino2

Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710,1 and Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8414,2 Japan

Received 20 July 2000/Returned for modification 27 November 2000/Accepted 12 January 2001

The Pseudomonas aeruginosa nfxB mutant lacking mexAB-oprM showed hypersusceptibility to 9 out of 24 beta -lactams tested. This hypersusceptibility was found for the nfxB mutant lacking mexAB-oprM-mexXY (N108) but not for the nfxB mutant lacking both mexAB-oprM-mexXY and ampC. The level of the AmpC beta -lactamase induction was reduced in N108. Thus, the reduced AmpC induction must be the cause of the hypersusceptibility.

* Corresponding author. Present address: Department of Genetics, Warren Alpert Building, Room 513, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115. Phone: (617) 432-7561. Fax: (617) 432-7266. E-mail: nmasud{at}shina.sankyo.co.jp.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1284-1286, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1284-1286.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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