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Antimicrobial Agents and Chemotherapy, April 2001, p. 1292-1294, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1292-1294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Combination Effect of Vancomycin and beta -Lactams against a Staphylococcus aureus Strain, Mu3, with Heterogeneous Resistance to Vancomycin

Nanae Aritaka, Hideaki Hanaki, Longzhu Cui, and Keiichi Hiramatsu*

Department of Bacteriology, Juntendo University, Tokyo, Japan

Received 12 April 2000/Returned for modification 7 June 2000/Accepted 18 January 2001

We tested the combined activity of vancomycin and seven beta -lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested beta -lactams exhibited an additive effect at or near their MICs, while all showed an antagonistic effect at lower, sub-MIC levels. This study implicated the unpredictable nature of combination therapy of beta -lactams and vancomycin against S. aureus with reduced susceptibility to vancomycin.

* Corresponding author. Mailing address: Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan, 113-8421. Phone: 81-3-5802-1040. Fax: 81-3-5684-7830. E-mail: hiram{at}med.juntendo.ac.jp.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1292-1294, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1292-1294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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