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Antimicrobial Agents and Chemotherapy, April 2001, p. 1309-1311, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1309-1311.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Diversity of Tn1546 Elements in Clinical Isolates of Glycopeptide-Resistant Enterococci from Scottish Hospitals

A. R. Brown, A. C. Townsley, and S. G. B. Amyes*

Department of Medical Microbiology, University of Edinburgh, Edinburgh, United Kingdom

Received 17 July 2000/Returned for modification 3 October 2000/Accepted 10 January 2001

The Tn1546-related elements of 48 Van glycopetide-resistant enterococci were compared. Ten distinct Tn1546 types were identified with variation primarily due to IS1542 and IS1216V-like insertions. Clonal isolates frequently differed in their Tn1546 type, indicating instability of Tn1546-related elements. A putative hybrid promoter was identified, generated upstream of vanR by the insertion of IS1542. The presence of this hybrid promoter was associated with constitutive expression of the van genes and elevated teicoplanin resistance.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, United Kingdom. Phone: 44-131-6503163. Fax: 44-131-6511385, E-mail: s.g.b.amyes{at}ed.ac.uk.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1309-1311, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1309-1311.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Biavasco, F., Foglia, G., Paoletti, C., Zandri, G., Magi, G., Guaglianone, E., Sundsfjord, A., Pruzzo, C., Donelli, G., Facinelli, B. (2007). VanA-Type Enterococci from Humans, Animals, and Food: Species Distribution, Population Structure, Tn1546 Typing and Location, and Virulence Determinants. Appl. Environ. Microbiol. 73: 3307-3319 [Abstract] [Full Text]  
  • Jung, W. K., Hong, S. K., Koo, H. C., Kwon, N. H., Park, Y. H. (2005). Nucleotide Sequence of IS1678, an Insertion Sequence in the vanA Cluster of Enterococci. Antimicrob. Agents Chemother. 49: 1666-1667 [Full Text]  
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