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Antimicrobial Agents and Chemotherapy, April 2001, p. 1312-1314, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1312-1314.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Blocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis

Regina A. Silva and Rui Appelberg*

Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal

Received 27 September 2000/Returned for modification 13 December 2000/Accepted 12 January 2001

High doses of Listeria monocytogenes overcome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria. This work shows that blocking the receptor for IL-10 may have useful therapeutic applications.

* Corresponding author. Mailing address: Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. Phone: 351.226074952. Fax: 351.226099157. E-mail: rappelb{at}ibmc.up.pt.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1312-1314, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1312-1314.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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