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Antimicrobial Agents and Chemotherapy, May 2001, p. 1558-1560, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1558-1560.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Synergistic Interactions between Mammalian Antimicrobial Defense Peptides

Hong Yan and Robert E. W. Hancock*

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3

Received 25 September 2000/Returned for modification 28 December 2000/Accepted 5 February 2001

A single animal can express several cationic antimicrobial peptides with different sequences and structures. We demonstrate that mammalian peptides from different structural classes frequently show synergy with each other and selectively show synergy with human lysozyme.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of British Columbia, 6174 University Blvd., Vancouver, British Columbia, Canada V6T 1Z3. Phone: (604) 822-2682. Fax: (604): 822-6041. E-mail: bob{at}cmdr.ubc.ca.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1558-1560, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1558-1560.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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