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Antimicrobial Agents and Chemotherapy, May 2001, p. 1561-1564, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1561-1564.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pharmacokinetics of Itraconazole Oral Solution in Neutropenic Children during Long-Term Prophylaxis

Claudine Schmitt,1 Yves Perel,2 Jean-luc Harousseau,3 Sophie Lemerle,4 Elisabeth Chwetzoff,5 Jean-Pierre le Moing,5 and Jean-Claude Levron5,*

Hôpital d'Enfants, Vandoeuvre les Nancy,1 Hôpital Pellegrin, Bordeaux,2 Hôtel Dieu, Nantes,3 Hôpital Intercommunal, Créteil,4 and Janssen Research Foundation, Val de Reuil,5 France

Received 10 April 2000/Returned for modification 26 August 2000/Accepted 8 February 2001

We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two groups of neutropenic children stratified by age. Effective concentrations of itraconazole in plasma were reached quickly and maintained throughout treatment. The results indicate a trend toward higher concentrations of itraconazole in plasma in older children.

* Corresponding author. Mailing address: Janssen Research Foundation, Campus de Maigremont, BP 615, 27106 Val de Reuil Cedex, France. Phone: 33-232-61-72-00. Fax: 33-232-61-72-98. E-mail: jlevron{at}jacfr.jnj.com.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1561-1564, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1561-1564.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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