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Antimicrobial Agents and Chemotherapy, May 2001, p. 1568-1571, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1568-1571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activity of Clarithromycin against Intracellular Helicobacter pylori

Raffaele Piccolomini,1,* Giovanni Di Bonaventura,1 Carla Picciani,1 Francesco Laterza,2 Jacopo Vecchiet,2 and Matteo Neri2

Departments of Biomedical Sciences, Clinical Microbiology Laboratory,1 and Medicine and Aging Sciences,2 G. D'Annunzio University, Chieti, Italy

Received 1 June 2000/Returned for modification 28 December 2000/Accepted 12 February 2001

The in vitro intracellular effect of clarithromycin, amoxicillin, metronidazole, lansoprazole, and rifabutin, tested at concentrations corresponding to one times the MIC, two times the MIC, and four times the MIC, was evaluated against an invasive Helicobacter pylori strain. At four times the MIC, clarithromycin showed an early bactericidal effect within 4 h of incubation and, in determining the complete killing within a 16 h-incubation period, lansoprazole and rifabutin showed comparable activity, yielding bactericidal activities within 4 and 8 h of incubation, respectively. Amoxicillin and metronidazole showed bacteriostatic activity only.

* Corresponding author. Mailing address: Laboratorio di Microbiologia Clinica, Dipartimento di Scienze Biomediche, Università "G. D'Annunzio," Via dei Vestini 31-66100 Chieti, Italy. Phone: (39) 0871- 355-52-83. Fax: (39) 0871-355-52-82. E-mail: r.piccolomini{at}dsb.unich.it.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1568-1571, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1568-1571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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