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Antimicrobial Agents and Chemotherapy, May 2001, p. 1578-1580, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1578-1580.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Macrolide Resistance in Streptococcus pneumoniae in Hong Kong

Margaret Ip,1,* Donald J. Lyon,1 Raymond W. H. Yung,2 Colin Chan,1 and Augustine F. B. Cheng1

Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin,1 and Pamela Youde Nethersole Eastern Hospital,2 Hong Kong, China

Received 17 August 2000/Returned for modification 31 January 2001/Accepted 15 February 2001

Erythromycin resistance rates among penicillin-susceptible Streptococcus pneumoniae were 38 and 92% among penicillin-intermediate and -resistant S. pneumoniae isolates from Hong Kong, respectively, and 27% (43 of 158) of the isolates showed the MLSB phenotype, and the majority carried the ermB gene; 73% (115 of 158) displayed the M phenotype, and all possessed the mef gene. The MLSB phenotype was predominant in penicillin-susceptible, macrolide-resistant isolates and in penicillin-nonsusceptible isolates of serotype 6B, whilst the M phenotype was predominant in penicillin-intermediate or -resistant isolates belonging to serotype 23F or 19F. Extensive spread of clones of drug-resistant pneumococci has led to the widespread presence of macrolide resistance in S. pneumoniae in Hong Kong.

* Corresponding author. Mailing address: Dept. of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. Phone: (852) 2632 2306. Fax: (852) 2647 3227. E-mail: margaretip{at}cuhk.edu.hk.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1578-1580, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1578-1580.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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