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Antimicrobial Agents and Chemotherapy, May 2001, p. 1589-1590, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1589-1590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Effect of Potassium on Saccharomyces cerevisiae Resistance to Fluconazole

Carlos A. Stella^* and Hilda I. Burgos

Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina

Received 13 December 2000/Returned for modification 4 January 2001/Accepted 15 February 2001

Susceptibility of strain S288c of Saccharomyces cerevisiae to fluconazole was assayed in the presence and absence of KCl. Addition of 150 mM KCl renders the strain more sensitive to the antifungal agent. The effect is caused by the K⁺ ion rather than the anion or the osmolarity of the medium. The increase in sensitivity does not modify the values of intracellular and extracellular pH established in the presence of KCl.

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^* Corresponding author. Mailing address: Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 5, 1121 Buenos Aires, Argentina. Fax: 4508-3672, ext. 31. E-mail: cstella{at}fmed.uba.ar.

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Antimicrobial Agents and Chemotherapy, May 2001, p. 1589-1590, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1589-1590.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.