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Antimicrobial Agents and Chemotherapy, June 2001, p. 1794-1798, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1794-1798.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Uptake, Transport, and Delivery of Antimicrobial Agents by Human Polymorphonuclear Neutrophils

Gerald L. Mandell* and Elizabeth Coleman

Division of Infectious Diseases, University of Virginia Health System, Charlottesville, Virginia 22908-1341

Received 20 July 2000/Returned for modification 19 December 2000/Accepted 7 March 2001

Polymorphonuclear neutrophils (PMN) are attracted to sites of infection. They have the potential to deliver antimicrobial agents to these sites if the agents enter the cells and do not alter migration. Penicillin G did not enter cells and was not transported by PMN. We found that azithromycin, ciprofloxacin, levofloxacin, moxifloxacin, and telithromycin were concentrated in PMN and transported toward a chemoattractant. These antimicrobial agents were released from the PMN and inhibited the growth of bacteria on test plates.

* Corresponding author. Mailing address: University of Virginia Health System, P.O. Box 801341, Division of Infectious Diseases, Charlottesville, VA 22908-1341. Phone: (804) 924-5942. Fax: (804) 982-0002. E-mail: gm{at}virginia.edu.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1794-1798, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1794-1798.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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