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Antimicrobial Agents and Chemotherapy, June 2001, p. 1872-1875, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1872-1875.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Activities of Hexadecylphosphocholine (Miltefosine), AmBisome, and Sodium Stibogluconate (Pentostam) against Leishmania donovani in Immunodeficient scid Mice

Patricia Escobar, Vanessa Yardley, and Simon L. Croft*

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom

Received 20 November 2000/Returned for modification 29 December 2000/Accepted 2 March 2001

In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltefosine was similar in peritoneal macrophages derived from both scid and BALB/c mice, whereas Pentostam and AmBisome were significantly more active in the latter.

* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Phone: 00 44 20 7927 2345. Fax: 00 44 20 7636 8739. E-mail: simon.croft{at}lshtm.ac.uk.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1872-1875, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1872-1875.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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