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Antimicrobial Agents and Chemotherapy, June 2001, p. 1930-1933, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1930-1933.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa

Kazuhiro Tateda,1 Rachel Comte,2 Jean-Claude Pechere,2 Thilo Köhler,2 Keizo Yamaguchi,1 and Christian Van Delden2,*

Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

Received 9 October 2000/Returned for modification 17 January 2001/Accepted 28 March 2001

We report that 2 µg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

* Corresponding author. Mailing address: Department of Genetics and Microbiology, Medical School of the University of Geneva, CMU, 9 av Champel, CH-1211 Geneva 14, Switzerland. Phone: (4122) 702 56 55. Fax: (4122) 702 57 02. E-mail: Christian.vanDelden{at}medecine.unige.ch.

Antimicrobial Agents and Chemotherapy, June 2001, p. 1930-1933, Vol. 45, No. 6
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.6.1930-1933.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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