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Antimicrobial Agents and Chemotherapy, July 2001, p. 2173-2176, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2173-2176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma

Holly L. Jordan,1,* Arlene S. Pereira,2 Myron S. Cohen,1 and Angela D. M. Kashuba3

Department of Medicine,1 Department of Pathology,2 and School of Pharmacy,3 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

Received 13 November 2000/Returned for modification 11 March 2001/Accepted 20 April 2001

To establish whether a feline model can predict nucleoside analogue behavior in human semen, zidovudine (ZDV) and lamivudine (3TC) pharmacokinetic parameters (PKs) were determined in the blood and seminal plasma of healthy cats. Our results show considerable similarity in ZDV and 3TC PKs between cats and humans. As in humans, ZDV and 3TC tend to accumulate in feline seminal plasma. Area under the blood plasma concentration-time curve was predictive of seminal plasma excretion. The felid model offers a unique in vivo experimental alternative for investigating the pharmacokinetics of nucleoside analogues in the male genital tract.

* Corresponding author. Mailing address: Department of Medicine, 547 Burnett-Womack, CB #7030, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7030. Phone: (919) 513-2819. Fax: (919) 515-4237. E-mail: holly_jordan{at}med.unc.edu.

Antimicrobial Agents and Chemotherapy, July 2001, p. 2173-2176, Vol. 45, No. 7
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.7.2173-2176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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