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Antimicrobial Agents and Chemotherapy, August 2001, p. 2386-2389, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2386-2389.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cloning and Biochemical Characterization of a Class A beta -Lactamase from Prevotella intermedia

I. Madinier,1,2 T. Fosse,2,* J. Giudicelli,3 and R. Labia4

Laboratoire de Pathobiologie Orale, Faculté de Chirurgie Dentaire, 06357 Nice Cedex 4,1 Laboratoire de Bactériologie, Hôpital l'Archet 2, 06202 Nice Cedex 3,2 Laboratoire de Biochimie, INSERM 145, Faculté de Médecine, 06107 Nice Cedex 2,3 and CNRS, UMR 175, 29000 Quimper,4 France

Received 1 August 2000/Returned for modification 10 November 2000/Accepted 11 May 2001

The gene encoding a beta -lactamase of Prevotella intermedia was cloned and sequenced. This gene, called cfxA2, shared 98% identity with cfxA, the structural gene of a beta -lactamase previously described in Bacteroides vulgatus. The deduced protein sequence had a K272E substitution. CfxA2 had the characteristics of class A, group 2e beta -lactamases.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Hôpital l'Archet 2, 151, route de Saint Antoine Ginestière, 06202 Nice Cedex 3, France. Phone: (33) (4) 92 03 62 14. Fax: (33) (4) 90 03 65 49. E-mail: fosse{at}unice.fr.

Antimicrobial Agents and Chemotherapy, August 2001, p. 2386-2389, Vol. 45, No. 8
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.8.2386-2389.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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