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Antimicrobial Agents and Chemotherapy, September 2001, p. 2635-2637, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2635-2637.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Antifungal Activities of the New Triazole UR-9825 against Clinically Important Filamentous Fungi

Javier Capilla, Montserrat Ortoneda, Francisco Javier Pastor, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Received 9 March 2001/Returned for modification 12 April 2001/Accepted 2 June 2001

We used a modified reference microdilution method (the M-38P method) to evaluate the in vitro activities of the new triazole UR-9825 in comparison with those of amphotericin B against 77 strains of opportunistic filamentous fungi. UR-9825 was clearly more active than amphotericin B against all fungi except Fusarium solani and Scytalidium spp. Notably, UR-9825 had low MICs for Aspergillus fumigatus and Paecilomyces lilacinus (MICs at which 90% of isolates are inhibited, 0.125 µg/ml for both species).

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: umb{at}fmcs.urv.es.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2635-2637, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2635-2637.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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