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Antimicrobial Agents and Chemotherapy, September 2001, p. 2648-2650, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2648-2650.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Emergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility

Anthony M. Smith,1,* Roelof F. Botha,2 Hendrik J. Koornhof,1 and Keith P. Klugman1,3

MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg,1 and Microbiology Department, Drs. du Buisson, Bruinette, and Kramer, Pretoria,2 South Africa, and Departments of International Health and Infectious Diseases, Emory University, Atlanta, Georgia3

Received 23 January 2001/Returned for modification 10 April 2001/Accepted 10 June 2001

We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.

* Corresponding author. Mailing address: MRC/SAIMR/WITS Pneumococcal Diseases Research Unit, Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, P.O. Box 1038, Johannesburg, 2000, South Africa. Phone: 27-011-4899335. Fax: 27-011-4899332. E-mail: anthonys{at}mail.saimr.wits.ac.za.

Antimicrobial Agents and Chemotherapy, September 2001, p. 2648-2650, Vol. 45, No. 9
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.9.2648-2650.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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