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Antimicrobial Agents and Chemotherapy, January 2002, p. 216-219, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.216-219.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Postneurosurgical Meningitis Due to Proteus penneri with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A ß-Lactamase HugA and its LysR-Type Regulatory Protein HugR

Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland,¹ Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper,² Centre de Biologie Marine, Unité FRE 2125, Concarneau, France³

Received 30 January 2001/ Returned for modification 29 May 2001/ Accepted 29 September 2001

We report on a case of a postneurosurgical meningitis due to ceftriaxone-susceptible Proteus penneri, with selection of a ceftriaxone-resistant isolate following treatment with ceftriaxone. The isolates presented identical patterns by pulsed-field gel electrophoresis and produced a single ß-lactamase named HugA with an isoelectric point of 6.7. The ceftriaxone-resistant isolate hyperproduced the ß-lactamase (increase in the level of production, about 90-fold). The sequences of the hugA ß-lactamase gene and its regulator, hugR, were identical in both P. penneri strains and had 85.96% homology with those of Proteus vulgaris. The HugA ß-lactamase belongs to molecular class A, and the transcriptional regulator HugR belongs to the LysR family.

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