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Antimicrobial Agents and Chemotherapy, January 2002, p. 220-224, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.220-224.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds

Dianne B. Hoellman,1 Linda M. Kelly,1 Kim Credito,1 Lauren Anthony,1 Lois M. Ednie,1 Michael R. Jacobs,2 and Peter C. Appelbaum1*

Department of Pathology (Clinical Microbiology), Hershey Medical Center, Hershey, Pennsylvania 17033,1 Department of Pathology (Clinical Microbiology), Case Western Reserve University, Cleveland, Ohio 441062

Received 28 March 2001/ Returned for modification 26 August 2001/ Accepted 25 September 2001

Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active ß-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 µg/ml; MIC90s, 1.0 to 2.0 µg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other ß-lactams were similar to those of ertapenem.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, January 2002, p. 220-224, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.220-224.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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