This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sponer, U.
Right arrow Articles by Wernsdorfer, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sponer, U.
Right arrow Articles by Wernsdorfer, W. H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2002, p. 262-264, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.262-264.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pharmacodynamic Interaction of Doxycycline and Artemisinin in Plasmodium falciparum

Ulrike Sponer,1,2 Somsak Prajakwong,3 Gerhard Wiedermann,1 Herwig Kollaritsch,1,2* Gunther Wernsdorfer,4 and Walther H. Wernsdorfer1,4

Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, A-1095 Vienna,1 Department of Clinical Pathology, University of Vienna, A-1090 Vienna Austria,2 Office of Vector-borne Disease Control, Region 2, 50100 Chiang Mai,3 Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand4

Received 19 January 2001/ Returned for modification 30 July 2001/ Accepted 15 October 2001

Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC50), EC90, and EC99 levels.

* Corresponding author. Mailing address: Department of Specific Prophylaxis and Tropical Medicine, Kinderspitalgasse 15, A-1095 Vienna, Austria. Phone: 42-1-403-83-43-22. Fax: 43-1-403-83-43-90. E-mail: herwig.kollaritsch{at}univie.ac.at.

Antimicrobial Agents and Chemotherapy, January 2002, p. 262-264, Vol. 46, No. 1
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.1.262-264.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Starzengruber, P., Thriemer, K., Haque, R., Khan, W. A., Fuehrer, H. P., Siedl, A., Hofecker, V., Ley, B., Wernsdorfer, W. H., Noedl, H. (2009). Antimalarial Activity of Tigecycline, a Novel Glycylcycline Antibiotic. Antimicrob. Agents Chemother. 53: 4040-4042 [Abstract] [Full Text]  
  • Batty, K. T., Law, A. S. F., Stirling, V., Moore, B. R. (2007). Pharmacodynamics of Doxycycline in a Murine Malaria Model. Antimicrob. Agents Chemother. 51: 4477-4479 [Abstract] [Full Text]  
  • Newton, P. N., Chaulet, J.-F., Brockman, A., Chierakul, W., Dondorp, A., Ruangveerayuth, R., Looareesuwan, S., Mounier, C., White, N. J. (2005). Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria. Antimicrob. Agents Chemother. 49: 1622-1625 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»