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Antimicrobial Agents and Chemotherapy, October 2002, p. 3280-3282, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3280-3282.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Use of Fluoroquinolones in Patients with Chronic Hepatitis C Virus-Induced Liver Failure

H. Kojima, K. D. E. Kaita, K. Hawkins, J. Uhanova, and G. Y. Minuk*

Liver Diseases Unit, University of Manitoba, Winnipeg, Manitoba, Canada

Received 19 March 2002/ Returned for modification 17 June 2002/ Accepted 15 July 2002

Fluroquinolone antibiotics have been reported to have antiviral properties against RNA viruses, including hepatitis C virus (HCV). In the present study, five patients with advanced liver disease secondary to chronic HCV received 500 mg daily of oral ciprofloxacin for 30 days. Serum HCV-RNA levels and liver enzyme abnormalities remained largely unchanged. Thus, the role of fluoroquinolones as antiviral agents for chronic HCV in patients with advanced liver disease appears to be limited.

* Corresponding author. Mailing address: Liver Diseases Unit, Health Sciences Centre, John Buhler Research Centre, 803-715 McDermot Ave., Winnipeg, MB R3E 3P4, Canada. Phone: (204) 789-3204. Fax: (204) 789-3971. E-mail: gminuk{at}cc.umanitoba.ca.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3280-3282, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3280-3282.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Coban, S., Ceydilek, B., Ekiz, F., Erden, E., Soykan, I. (2005). Levofloxacin-Induced Acute Fulminant Hepatic Failure in a Patient with Chronic Hepatitis B Infection. The Annals of Pharmacotherapy 39: 1737-1740 [Abstract] [Full Text]  


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