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Antimicrobial Agents and Chemotherapy, October 2002, p. 3298-3300, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3298-3300.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Investigational Triazoles against Fusarium Species: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results

Niki I. Paphitou,* Luis Ostrosky-Zeichner, Victor L. Paetznick, Jose R. Rodriguez, Enuo Chen, and John H. Rex

Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas-Houston Medical School, Houston, Texas 77030

Received 17 May 2002/ Returned for modification 2 July 2002/ Accepted 17 July 2002

We studied the effects of inoculum size and incubation time on the susceptibility testing results for various antifungal agents against 22 Fusarium isolates by the NCCLS microdilution method. Increased inoculum size and extended incubation time resulted in elevated MICs. Posaconazole and voriconazole exhibited promising antifungal activities.

* Corresponding author. Present address: 1 Iona Nicolaou St., Aglanjia, Nicosia 2108, Cyprus. Phone: (357) 22335565. Fax: (357) 22769225. E-mail: GMIX{at}msn.com.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3298-3300, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3298-3300.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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