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Antimicrobial Agents and Chemotherapy, October 2002, p. 3334-3336, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3334-3336.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Gene Dosage and Linezolid Resistance in Enterococcus faecium and Enterococcus faecalis

S. H. Marshall, C. J. Donskey, R. Hutton-Thomas, R. A. Salata, and L. B. Rice*

Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio

Received 15 March 2002/ Returned for modification 30 May 2002/ Accepted 18 July 2002

Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.

* Corresponding author. Mailing address: Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4801. Fax: (216) 231-3289. E-mail: louis.rice{at}med.va.gov.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3334-3336, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3334-3336.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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