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Antimicrobial Agents and Chemotherapy, November 2002, p. 3613-3616, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3613-3616.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Stampidine Is a Potent Inhibitor of Zidovudine- and Nucleoside Analog Reverse Transcriptase Inhibitor-Resistant Primary Clinical Human Immunodeficiency Virus Type 1 Isolates with Thymidine Analog Mutations

Fatih M. Uckun,1,2* Sharon Pendergrass,1,2 T. K. Venkatachalam,1,2 Sanjive Qazi,1,2 and Douglas Richman3,4,5

Drug Discovery Program, Departments of Virology, Bioinformatics, Immunology, and Chemistry, Parker Hughes Institute, St. Paul,1 Parker Hughes Center for Clinical Immunology, Roseville, Minnesota,2 Virology Section,3 Departments of Pathology and Medicine, University of California, San Diego,4 VA San Diego Healthcare System, La Jolla, California5

Received 6 February 2002/ Returned for modification 19 June 2002/ Accepted 15 July 2002

We report the antiretroviral activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates. STAMP inhibited each one of nine clinical HIV-1 isolates of non-B envelope subtype and 20 genotypically and phenotypically nucleoside analog reverse transcriptase inhibitor-resistant HIV-1 isolates at subnanomolar to low-nanomolar concentrations.

* Corresponding author. Mailing address: Parker Hughes Institute, 2657 Patton Rd., St. Paul, MN 55113. Phone: (651) 796-5400. Fax: (651) 697-1042. E-mail: fatih_uckun{at}ih.org.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3613-3616, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3613-3616.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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