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Antimicrobial Agents and Chemotherapy, November 2002, p. 3648-3649, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3648-3649.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vivo Penicillin MIC Drift to Extremely High Resistance in Serotype 14 Streptococcus pneumoniae Persistently Colonizing the Nasopharynx of an Infant with Chronic Suppurative Lung Disease: a Case Study

Amanda J. Leach,* Peter S. Morris, Heidi Smith-Vaughan, and John D. Mathews{dagger}

Menzies School of Health Research, Darwin, Northern Territory, Australia

Received 5 December 2001/ Returned for modification 29 January 2002/ Accepted 5 August 2002

This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics.

* Corresponding author. Mailing address: Menzies School of Health Research, P.O. Box 41096, Casuarina 0811, Northern Territory, Australia. Phone: 61 8 8922 8196. Fax: 61 8 89275 187. E-mail: amanda{at}menzies.edu.au.

{dagger} Present address: Department of Health and Aged Care, Canberra, Australian Capital Territory, Australia.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3648-3649, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3648-3649.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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