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Antimicrobial Agents and Chemotherapy, November 2002, p. 3665-3668, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3665-3668.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Integrons in Epidemiologically Unrelated Clinical Isolates of Acinetobacter baumannii from Italian Hospitals Reveals a Limited Diversity of Gene Cassette Arrays

Francesca Gombac,1 Maria Letizia Riccio,2 Gian Maria Rossolini,2 Cristina Lagatolla,1 Enrico Tonin,1 Carlo Monti-Bragadin,1 Annamaria Lavenia,1 and Lucilla Dolzani1*

Dipartimento di Scienze Biomediche, Sezione di Microbiologia, Università di Trieste, I-34127 Trieste,1 Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy2

Received 23 January 2002/ Returned for modification 6 May 2002/ Accepted 9 August 2002

Integron carriage by 36 epidemiologically unrelated Acinetobacter baumannii isolates collected over an 11-year period from patients in six different Italian hospitals was investigated. Sixteen type 1 integron-positive isolates (44%) were found, 13 of which carried the same array of cassettes, i.e., aacC1, orfX, orfX', and aadA1a. As ribotype analysis of the isolates demonstrated a notable genetic diversity, horizontal transfer of the entire integron structure or ancient acquisition was hypothesized.

* Corresponding author. Mailing address: Dipartimento di Scienze Biomediche, Sezione di Microbiologia, via Fleming, 22, I-34127 Trieste, Italy. Phone: 39 040 676 7184. Fax: 39 040 351668. E-mail: Dolzani{at}dsbmail.units.it.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3665-3668, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3665-3668.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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