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Antimicrobial Agents and Chemotherapy, November 2002, p. 3676-3678, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3676-3678.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Sequential Emergence of Antibiotic Resistance in Enterococcal Bloodstream Isolates over 25 Years

David R. Murdoch,1* Stanley Mirrett,1 Lizzie J. Harrell,1 Janet S. Monahan,2 and L. Barth Reller1

Clinical Microbiology Laboratories, Duke University Medical Center, Durham, North Carolina 27710,1 University of Colorado Hospital, Denver, Colorado2

Received 27 August 2001/ Returned for modification 7 November 2001/ Accepted 25 July 2002

We determined the antibiotic susceptibilities of 1,785 enterococcal bloodstream isolates collected over 25 years. Antibiotic resistance emerged at a greater rate in Enterococcus faecium than in other enterococcal species, and E. faecium isolates became proportionally more common over time. Our findings confirm the pattern of emerging antibiotic resistance among enterococci and highlight the increasing importance of E. faecium as a cause of bloodstream infection.

* Corresponding author. Present address: Microbiology Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand. Phone: 64 3 364 1530. Fax: 64 3 364 0238. E-mail: david.murdoch{at}cdhb.govt.nz.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3676-3678, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3676-3678.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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