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Antimicrobial Agents and Chemotherapy, December 2002, p. 3995-3996, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.3995-3996.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Garenoxacin (BMS 284756) against 108 Clinical Isolates of Gardnerella vaginalis

Ellie J. C. Goldstein,* Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell, and Helen T. Fernandez

R. M. Alden Research Laboratory, Santa Monica-University of California Los Angeles Medical Center, Santa Monica, California 90404, and the University of California Los Angeles School of Medicine, Los Angeles, California 90073

Received 25 April 2002/ Returned for modification 30 July 2002/ Accepted 8 September 2002

Garenoxacin (BMS 284756) was active against 105 of 108 (97%) recent clinical Gardnerella vaginalis isolates at <=2 µg/ml by using the reference agar dilution method for anaerobes. Twenty-eight percent of isolates (31 of 108) were resistant to metronidazole, and 44% were resistant to doxycycline. All were susceptible to clindamycin and ampicillin-sulbactam.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, December 2002, p. 3995-3996, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.3995-3996.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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