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Antimicrobial Agents and Chemotherapy, December 2002, p. 4035-4037, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4035-4037.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Promoters P3, Pa/Pb, P4, and P5 Upstream from blaTEM Genes and Their Relationship to ß-Lactam Resistance

Marie Frédérique Lartigue,1,2 Véronique Leflon-Guibout,1,2 Laurent Poirel,3,4 Patrice Nordmann,3,4 and Marie-Hélène Nicolas-Chanoine1,2*

Service de Microbiologie-Hygiène, Hôpital Ambroise Paré Assistance Publique-Hôpitaux de Paris, Boulogne,1 Faculté Paris Ile-de-France Ouest, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines,2 Service de Bactériologie-Virologie, Hôpital Bicêtre,3 Assistance Publique-Hôpitaux de Paris,4 Le Kremlin Bicêtre, and Faculté de Médecine Université Paris XI, Paris, France5

Received 23 May 2002/ Returned for modification 24 July 2002/ Accepted 25 August 2002

Using an isogenic system, we have determined the impact that the four promoters known to control blaTEM gene expression have on ß-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter P5, only found upstream of the blaTEM-1B gene, was related to the highest expression of this gene.

* Corresponding author. Mailing address: Hôpital Ambroise Paré, Service de Microbiologie-Hygiène, 9 avenue Charles de Gaulle, 92100 Boulogne Billancourt, France. Phone: 33-1-49-09-55-40. Fax: 33-1-49-09-59-21. E-mail: marie-helene.nicolas-chanoine{at}apr.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4035-4037, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4035-4037.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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