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Antimicrobial Agents and Chemotherapy, February 2002, p. 522-524, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.522-524.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Selection of Streptococcus pneumoniae Mutants Having Reduced Susceptibility to Moxifloxacin and Levofloxacin

Xinying Li, Xilin Zhao, and Karl Drlica*

Public Health Research Institute, New York, New York 10016

Received 10 July 2001/ Returned for modification 16 October 2001/ Accepted 6 November 2001

With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more effective than levofloxacin at restricting selection of resistant mutants and at killing resistant mutants, respectively. The selection frequency for first-step topoisomerase mutants was 1,000 times lower for moxifloxacin than for levofloxacin; this difference was lost when second-step mutants were selected.

* Corresponding author. Mailing address: Public Health Research Institute, 455 First Ave., New York, NY 10016. Phone: (212) 578-0830. Fax: (212) 578-0804. E-mail: drlica{at}phri.nyu.edu.

Antimicrobial Agents and Chemotherapy, February 2002, p. 522-524, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.522-524.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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