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Antimicrobial Agents and Chemotherapy, February 2002, p. 556-557, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.556-557.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Azole Cross-Resistance in Aspergillus fumigatus

J. Mosquera1 and D. W. Denning1,2*

School of Medicine, University of Manchester, Manchester M13 9PT,1 Department of Medicine, Wythenshawe Hospital, Manchester M29 9LT, United Kingdom2

Received 4 June 2001/ Returned for modification 7 August 2001/ Accepted 22 October 2001

We susceptibility tested 17 clinical isolates of Aspergillus fumigatus, for most of which MICs of itraconazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 µg/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.

* Corresponding author. Mailing address: Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M29 9LT, United Kingdom. Phone: 44 161 291 5054. Fax: 44 161 291 5020. E-mail: ddenning{at}man.ac.uk..

Antimicrobial Agents and Chemotherapy, February 2002, p. 556-557, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.556-557.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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