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Antimicrobial Agents and Chemotherapy, February 2002, p. 558-560, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.558-560.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus

Zhi-Qing Hu,1* Wei-Hua Zhao,1 Nozomi Asano,1 Yoshiyuki Yoda,1 Yukihiko Hara,2 and Tadakatsu Shimamura1

Department of Microbiology and Immunology, Showa University School of Medicine,1 Tokyo Food Techno Co. Ltd., Tokyo, Japan2

Received 13 April 2001/ Returned for modification 22 August 2001/ Accepted 25 October 2001

Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 µg/ml, were restored to the susceptible breakpoint (<=4 µg/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Phone: 81-3-3784-8131. Fax: 81-3-3784-3069. E-mail: zqhu{at}med.showa-u.ac.jp.

Antimicrobial Agents and Chemotherapy, February 2002, p. 558-560, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.558-560.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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