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Antimicrobial Agents and Chemotherapy, February 2002, p. 590-593, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.590-593.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Characterization of Mutations in DNA Gyrase and Topoisomerase IV Involved in Quinolone Resistance of Mycoplasma gallisepticum Mutants Obtained In Vitro

A. K. Reinhardt,1 C. M. Bébéar,2 M. Kobisch,1 I. Kempf,1 and A. V. Gautier-Bouchardon1*

Agence Française de Sécurité Sanitaire des Aliments, Laboratoire d'Etudes et de Recherches Avicoles et Porcines, Unité de Mycoplasmologie-Bactériologie, 22440 Ploufragan,1 Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France2

Received 7 May 2001/ Returned for modification 24 August 2001/ Accepted 1 November 2001

Mycoplasma gallisepticum enrofloxacin-resistant mutants were generated by stepwise selection in increasing concentrations of enrofloxacin. Alterations were found in the quinolone resistance-determining regions of the four target genes encoding DNA gyrase and topoisomerase IV from these mutants. This is the first description of such mutations in an animal mycoplasma species.

* Corresponding author. Mailing address: Agence Française de Sécurité Sanitaire des Aliments, Laboratoire d'Etudes et de Recherches Avicoles et Porcines, Unité de Mycoplasmologie-Bactériologie, Zoopole Les Croix, BP 53, 22440 Ploufragan, France. Phone: 33-2-96-01-62-86. Fax: 33-2-96-01-62-73. E-mail: a.bouchardon{at}ploufragan.afssa.fr.

Antimicrobial Agents and Chemotherapy, February 2002, p. 590-593, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.590-593.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Bebear, C. M., Renaudin, H., Charron, A., Clerc, M., Pereyre, S., Bebear, C. (2003). DNA Gyrase and Topoisomerase IV Mutations in Clinical Isolates of Ureaplasma spp. and Mycoplasma hominis Resistant to Fluoroquinolones. Antimicrob. Agents Chemother. 47: 3323-3325 [Abstract] [Full Text]  
  • Reinhardt, A. K., Kempf, I., Kobisch, M., Gautier-Bouchardon, A. V. (2002). Fluoroquinolone resistance in Mycoplasma gallisepticum: DNA gyrase as primary target of enrofloxacin and impact of mutations in topoisomerases on resistance level. J Antimicrob Chemother 50: 589-592 [Abstract] [Full Text]  


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