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Antimicrobial Agents and Chemotherapy, March 2002, p. 875-878, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.875-878.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of Acinetobacter baumannii

José María Saugar,1 Teresa Alarcón,2 Susana López-Hernández,2 Manuel López-Brea,2 David Andreu,3,{dagger} and Luis Rivas1*

Centro de Investigaciones Biológicas (CSIC),1 Servicio de Microbiología, Hospital Universitario de la Princesa, E-28006 Madrid,2 Department of Organic Chemistry, Universitat de Barcelona, E-08028 Barcelona, Spain3

Received 3 August 2001/ Returned for modification 21 September 2001/ Accepted 21 November 2001

Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH2) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter.

* Corresponding author. Mailing address: Centro de Investigaciones Biologicas, Velazquez 144, E-28006 Madrid, Spain. Phone: (34)915644562/4234. Fax: (34)915627518. E-mail: luis_rivas{at}cib.csic.es.

{dagger} Present address: Department of Experimental and Health Sciences, Universitat Pompeu Fabra; E-08003 Barcelona, Spain.

{dagger} Present address: Department of Experimental and Health Sciences, Universitat Pompeu Fabra; E-08003 Barcelona, Spain.

Antimicrobial Agents and Chemotherapy, March 2002, p. 875-878, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.875-878.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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