This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scovill, J.
Right arrow Articles by Shapiro, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scovill, J.
Right arrow Articles by Shapiro, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2002, p. 882-883, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.882-883.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antitrypanosomal Activities of Tryptanthrins

John Scovill,1 Elizabeth Blank,1 Michael Konnick,1 Elizabeth Nenortas,2 and Theresa Shapiro2*

Department of Chemistry, Bucknell University, Lewisburg, Pennsylvania 17837,1 Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-21852

Received 18 April 2001/ Returned for modification 18 June 2001/ Accepted 28 November 2001

New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 µM.

* Corresponding author. Mailing address: Johns Hopkins School of Medicine, 303 Hunterian Building, 725 North Wolfe St., Baltimore, MD 21205. Phone: (410) 955-1888. Fax: (410) 955-2634. E-mail: tshapiro{at}jhmi.edu.

Antimicrobial Agents and Chemotherapy, March 2002, p. 882-883, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.882-883.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Krivogorsky, B., Grundt, P., Yolken, R., Jones-Brando, L. (2008). Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs. Antimicrob. Agents Chemother. 52: 4466-4469 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»