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Antimicrobial Agents and Chemotherapy, March 2002, p. 900-903, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.900-903.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Penetration of Rifampin through Staphylococcus epidermidis Biofilms

Zhilan Zheng and Philip S. Stewart*

Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University—Bozeman, Bozeman, Montana 59717-3980

Received 4 June 2001/ Returned for modification 16 August 2001/ Accepted 19 October 2001

Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.

* Corresponding author. Mailing address: Center for Biofilm Engineering, Montana State University—Bozeman, Bozeman, MT 59717-3980. Phone: (406) 994-2890. Fax: (406) 994-6098. E-mail: phil_s{at}erc.montana.edu.

Antimicrobial Agents and Chemotherapy, March 2002, p. 900-903, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.900-903.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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