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Antimicrobial Agents and Chemotherapy, April 2002, p. 1108-1111, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1108-1111.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Activities of a Novel Cephalosporin, BMS-247243, against Organisms other than Staphylococci

Junius Clark, Joan C. Fung-Tomc,* Beatrice Minassian, Yuan-Hwang Tsai, Hyekyung Yang, Elizabeth Huczko, Benjamin Kolek, Susan Chaniewski, Cheryl Ferraro, Rebecca Drain, Elizabeth Gradelski, and Daniel P. Bonner

Department of Microbiology, Bristol-Myers Squibb Co., Wallingford, Connecticut 06492

Received 23 March 2001/ Returned for modification 27 October 2001/ Accepted 2 January 2002

BMS-247243, a novel cephalosporin inhibitory for methicillin-resistant staphylococci, primarily has activity against gram-positive bacteria. The activities of BMS-247243, cefotaxime, and ceftriaxone against streptococci and Streptococcus pneumoniae were similar. BMS-247243 inhibits Enterococcus faecalis but not Enterococcus faecium. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

* Corresponding author. Mailing address: Department of Microbiology-104, Bristol-Myers Squibb Co., 5 Research Pkwy., Wallingford, CT 06492. Phone: (203) 677-6370. Fax: (203) 677-6771. E-mail: fungtomj{at}bms.com.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1108-1111, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1108-1111.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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