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Antimicrobial Agents and Chemotherapy, April 2002, p. 1125-1127, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1125-1127.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparison of Oral Artesunate and Dihydroartemisinin Antimalarial Bioavailabilities in Acute Falciparum Malaria

Paul N. Newton,1,2 Michele van Vugt,1,3,4 Paktiya Teja-Isavadharm,5 Duangsuda Siriyanonda,5 Maneerat Rasameesoroj,5 Pramote Teerapong,6 Ronatrai Ruangveerayuth,7 Thra Slight,3 Francois Nosten,1,3 Yupin Suputtamongkol,8 Sornchai Looareesuwan,1 and Nicholas J. White1,2,3*

Faculty of Tropical Medicine,1 Department of Pharmacology, Faculty of Pharmacy Mahidol University,6 Mahidol University, Shoklo Malaria Research Unit,3 Mae Sot Hospital, Mae Sot, Tak Province,7 Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences,5 Department of Medicine, Siriraj Hospital, Bangkok, Thailand,8 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom,2 Academic Medical Centre, Amsterdam, The Netherlands4

Received 8 September 2000/ Returned for modification 29 January 2001/ Accepted 23 November 2001

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

* Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: (66) 2 246 0832. Fax: (66) 2 246 7795. E-mail: fnnjw{at}diamond.mahidol.ac.th.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1125-1127, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1125-1127.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Woodrow, C J, Haynes, R K, Krishna, S (2005). Artemisinins. Postgrad. Med. J. 81: 71-78 [Abstract] [Full Text]  
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