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Antimicrobial Agents and Chemotherapy, April 2002, p. 1136-1140, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1136-1140.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activities of Ertapenem (MK-0826) against 469 Less Frequently Identified Anaerobes Isolated from Human Infections

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 and Helen Fernandez1

R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404 ,1 School of Medicine, University of California, Los Angeles, Los Angeles, California 900242

Received 16 May 2001/ Returned for modification 25 November 2001/ Accepted 26 December 2001

We studied the in vitro activity of ertapenem against 469 less frequently identified anaerobes from 11 genera and 52 species isolated from human infections. Ertapenem was uniformly active against 460 of 469 (98%) strains at concentrations of <=4 µg/ml. Only 4 of 14 Clostridium difficile, 1 of 11 Clostridium innocuum, and 4 of 6 Lactobacillus sp. strains required ertapenem concentrations of >=8 µg/ml for inhibition.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite #740E, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1136-1140, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1136-1140.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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