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Antimicrobial Agents and Chemotherapy, April 2002, p. 1144-1146, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1144-1146.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Antifungal Susceptibilities of Trichosporon Species

Niki I. Paphitou,* Luis Ostrosky-Zeichner, Victor L. Paetznick, Jose R. Rodriguez, Enuo Chen, and John H. Rex

Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas—Houston Medical School, Houston, Texas 77030

Received 10 October 2001/ Returned for modification 12 December 2001/ Accepted 15 January 2002

The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC ratios were observed for voriconazole, posaconazole, and ravuconazole, suggesting fungicidal activity.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Texas-Houston Medical School, 6431 Fannin JFB 1.728, Houston, TX 77030. Phone: (713) 500-6767. Fax: (713) 500-5495. E-mail: Elpida-Niki.I.Paphitou{at}uth.tmc.edu.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1144-1146, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1144-1146.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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