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Antimicrobial Agents and Chemotherapy, May 2002, p. 1589-1590, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1589-1590.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Single-Dose Pharmacokinetics of Amprenavir Coadministered with Grapefruit Juice

D. Demarles,^1* C. Gillotin,¹ S. Bonaventure-Paci,² I. Vincent,² S. Fosse,¹ and A. M. Taburet²

Laboratoire Glaxo SmithKline, Marly-le-Roi,¹ Bicêtre Hospital, Paris, France²

Received 16 October 2001/ Returned for modification 17 January 2002/ Accepted 4 February 2002

In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (C_max) compared to administration with water (7.11 versus 9.10 µg/ml), slightly increased the time to C_max (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h (AUC_0-12), the AUC_0-, or the concentration at 12 h. Therefore, grapefruit juice does not clinically significantly affect amprenavir pharmacokinetics.

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* Corresponding author. Mailing address: Clinical Pharmacology Unit, GlaxoSmithKline, 100 route de Versailles, Marly-le-Roi, Yvelines 78163, France. Phone: 33 1 39 17 93 71. Fax: 33 1 39 17 86 87. E-mail: dd79951{at}gsk.com.

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Antimicrobial Agents and Chemotherapy, May 2002, p. 1589-1590, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1589-1590.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

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