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Antimicrobial Agents and Chemotherapy, May 2002, p. 1594-1596, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1594-1596.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients

Corrado Blandizzi,1 Tecla Malizia,2 Giovanna Batoni,2 Emilia Ghelardi,2 Fabio Baschiera,1 Paolo Bruschini,3 Sonia Senesi,2 Mario Campa,2 and Mario Del Tacca1*

Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine,1 Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology,2 Division of Otorhinolaryngology, University Hospital of Pisa, Pisa, Italy3

Received 17 May 2001/ Returned for modification 13 November 2001/ Accepted 26 January 2002

Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.

* Corresponding author. Mailing address: Divisione di Farmacologia e Chemioterapia, Dipartimento di Oncologia, dei Trapianti, e delle Nuove Tecnologie in Medicina, Università di Pisa, Via Roma 55, I-56126 Pisa, Italy. Phone: 39-050-830148. Fax: 39-050-562020. E-mail: m.deltacca{at}do.med.unipi.it.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1594-1596, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1594-1596.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Danesi, R., Lupetti, A., Barbara, C., Ghelardi, E., Chella, A., Malizia, T., Senesi, S., Angeletti, C. A., Del Tacca, M., Campa, M. (2003). Comparative distribution of azithromycin in lung tissue of patients given oral daily doses of 500 and 1000 mg. J Antimicrob Chemother 51: 939-945 [Abstract] [Full Text]  


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