This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castro, N.
Right arrow Articles by Sotelo, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castro, N.
Right arrow Articles by Sotelo, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2002, p. 1614-1616, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1614-1616.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Interaction between Grapefruit Juice and Praziquantel in Humans

Nelly Castro,1,2* Helgi Jung,1,2 Roberto Medina,2 Dinora González-Esquivel,1 Mario Lopez,1 and Julio Sotelo1,2

Instituto Nacional de Neurología y Neurocirugía,1 Universidad Nacional Autonoma de Mexico, Mexico City, Mexico2

Received 26 April 2001/ Returned for modification 25 November 2001/ Accepted 6 February 2002

After a single oral dose of praziquantel with 250 ml of grapefruit juice, the area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased (Cmax for water treatment, 637.71 ± 128.5 ng/ml; and Cmax for grapefruit juice treatment, 1,037.65 ± 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life.

* Corresponding author. Mailing address: Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, 14269, Mexico City, Mexico. Phone and fax: (52) 5 424 08 08. E-mail: nnct{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1614-1616, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1614-1616.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mertens-Talcott, S. U., Zadezensky, I., De Castro, W. V., Derendorf, H., Butterweck, V. (2006). Grapefruit-drug interactions: can interactions with drugs be avoided?. J Clin Pharmacol 46: 1390-1416 [Abstract] [Full Text]  
  • Utzinger, J., Keiser, J., Shuhua, X., Tanner, M., Singer, B. H. (2003). Combination Chemotherapy of Schistosomiasis in Laboratory Studies and Clinical Trials. Antimicrob. Agents Chemother. 47: 1487-1495 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»