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Antimicrobial Agents and Chemotherapy, June 2002, p. 2000-2003, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2000-2003.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

TEM-71, a Novel Plasmid-Encoded, Extended-Spectrum ß-Lactamase Produced by a Clinical Isolate of Klebsiella pneumoniae

J. Kamile Rasheed,1* Gregory J. Anderson,1 Anne Marie Queenan,2 James W. Biddle,1 Antonio Oliver,3 George A. Jacoby,4,5 Karen Bush,2 and Fred C. Tenover1

Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 The R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869,2 Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain,3 Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts 01730,4 Lahey Clinic, Burlington, Massachusetts 018055

Received 18 July 2001/ Returned for modification 27 September 2001/ Accepted 15 March 2002

TEM-71, a novel extended-spectrum ß-lactamase from a Klebsiella pneumoniae clinical isolate, had an isoelectric point of 6.0 and a substrate profile showing preferential hydrolysis of cefotaxime over ceftazidime. It differed from TEM-1 by two substitutions, Gly238Ser and Glu240Lys, and was under the control of the strong P4 promoter.

* Corresponding author. Mailing address: Anti-Infectives Section (G08), Centers for Disease Control and Prevention, 1600 Clifton Rd. N.E., Atlanta, GA 30333. Phone: (404) 639-3247. Fax: (404) 639-1381. E-mail: Jkr1{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2000-2003, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2000-2003.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Jacoby, G. A., Walsh, K. E., Walker, V. J. (2006). Identification of Extended-Spectrum, AmpC, and Carbapenem- Hydrolyzing {beta}-Lactamases in Escherichia coli and Klebsiella pneumoniae by Disk Tests.. J. Clin. Microbiol. 44: 1971-1976 [Abstract] [Full Text]  
  • Vignoli, R., Cordeiro, N. F., Garcia, V., Mota, M. I., Betancor, L., Power, P., Chabalgoity, J. A., Schelotto, F., Gutkind, G., Ayala, J. A. (2006). New TEM-Derived Extended-Spectrum {beta}-Lactamase and Its Genomic Context in Plasmids from Salmonella enterica Serovar Derby Isolates from Uruguay. Antimicrob. Agents Chemother. 50: 781-784 [Abstract] [Full Text]  


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