This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kilvington, S.
Right arrow Articles by Dart, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kilvington, S.
Right arrow Articles by Dart, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2002, p. 2007-2009, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2007-2009.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activities of Therapeutic Agents and Myristamidopropyl Dimethylamine against Acanthamoeba Isolates

Simon Kilvington,1* Reanne Hughes,1 James Byas,1 and John Dart2

Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN,1 Department of Ophthalmology, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom2

Received 7 January 2002/ Returned for modification 2 February 2002/ Accepted 5 March 2002

The activities of therapeutic agents and myristamidopropyl dimethylamine (MAPD) against Acanthamoeba strains recalcitrant to medical therapy were studied. MAPD minimum cysticidal concentrations were 6.25 to 25 µg/ml; 10 to 30 µg/ml gave at least a 3-log cyst kill after 6 h, and 50 and 100 µg/ml gave at least a 3-log cyst kill within 2 and 1 h, respectively.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Leicester, Medical Sciences Building, PO Box 138, University Road, Leicester LE1 9HN, United Kingdom. Phone: 44 (0) 116 252 2950. Fax: 44 (0) 116 252 5030. E-mail: sk46{at}leicester.ac.uk.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2007-2009, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2007-2009.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Furnkranz, U., Nagl, M., Gottardi, W., Kohsler, M., Aspock, H., Walochnik, J. (2008). Cytotoxic Activity of N-Chlorotaurine on Acanthamoeba spp.. Antimicrob. Agents Chemother. 52: 470-476 [Abstract] [Full Text]  
  • Hughes, R., Heaselgrave, W., Kilvington, S. (2003). Acanthamoeba polyphaga Strain Age and Method of Cyst Production Influence the Observed Efficacy of Therapeutic Agents and Contact Lens Disinfectants. Antimicrob. Agents Chemother. 47: 3080-3084 [Abstract] [Full Text]  
  • Hughes, R., Dart, J., Kilvington, S. (2003). Activity of the amidoamine myristamidopropyl dimethylamine against keratitis pathogens. J Antimicrob Chemother 51: 1415-1418 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»