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Antimicrobial Agents and Chemotherapy, June 2002, p. 2038-2040, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2038-2040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antitrypanosomal Activities of Proteasome Inhibitors

Joseph Nkemgu-Njinkeng,1 Vera Rosenkranz,2 Michael Wink,2 and Dietmar Steverding1*

Abteilung Parasitologie, Hygiene-Institut,1 Institut für Pharmazeutische Biologie, Ruprecht-Karls-Universität, Heidelberg, Germany2

Received 15 October 2001/ Returned for modification 27 November 2001/ Accepted 20 March 2002

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

* Corresponding author. Mailing address: School of Biological Sciences, University of Bristol, Woodland Rd., Bristol BS8 1UG, United Kingdom. Phone: 44-117-9288254. Fax: 44-117-9257374. E-mail: dsteverding{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2038-2040, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2038-2040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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