AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Delorenzi, J. C.
Right arrow Articles by Saraiva, E. M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delorenzi, J. C.
Right arrow Articles by Saraiva, E. M. B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2002, p. 2111-2115, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2111-2115.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine against Leishmania amazonensis

Jan Carlo Delorenzi,1,2 Leonardo Freire-de-Lima,1 Cerli R. Gattass,2 Deise de Andrade Costa,2 Liwen He,3 Martin E. Kuehne,3 and Elvira M. B. Saraiva1*

Departamento de Imunologia, Instituto de Microbiologia,1 Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil,2 Department of Chemistry, University of Vermont, Burlington, Vermont3

Received 5 November 2001/ Returned for modification 11 January 2002/ Accepted 27 March 2002

In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against Leishmania amazonensis, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.

* Corresponding author. Mailing address: Universidade Federal do Rio de Janeiro, Departamento de Imunologia, Instituto de Microbiologia, CCS, Bloco I, Sala 052, Ilha do Fundão, Rio de Janeiro, RJ 21944-970, Brazil. Phone: 55 (21) 2562-6747. Fax: 55 (21) 2560-8028. E-mail: esaraiva{at}micro.ufrj.br.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2111-2115, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2111-2115.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.