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Antimicrobial Agents and Chemotherapy, July 2002, p. 2299-2302, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2299-2302.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparison of Corticosteroids for Treatment of Respiratory Syncytial Virus Bronchiolitis and Pneumonia in Cotton Rats

Martin G. Ottolini,^1* Spencer J. Curtis,^2, David D. Porter,³ Amy Mathews,² Joann Y. Richardson,¹ Val G. Hemming,⁴ and Gregory A. Prince²

Department of Pediatrics,¹ Office of the Dean, F. Edward Hébert School of Medicine of the Uniformed Services University of the Health Sciences, Bethesda,⁴ Virion Systems Inc., Rockville, Maryland,² Department of Pathology of the University of California at Los Angeles, Los Angeles, California³

Received 17 October 2001/ Returned for modification 7 January 2002/ Accepted 26 March 2002

Triamcinolone acetonide, methylprednisolone, and dexamethasone were each evaluated in combination with palivizumab (Synagis) for the therapy of established respiratory syncytial virus infection in the cotton rat. Triamcinolone and methylprednisolone proved to be more effective than dexamethasone in reducing lung pathology. No recurrence of viral replication or pulmonary pathology followed the cessation of therapy.

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* Corresponding author. Mailing address: Department of Pediatrics, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Phone: (301) 295-3130. Fax: (301) 295-3898. E-mail: MOTTOLINI{at}USUHS.MIL.

Present address: The Uniformed Services University of the Health Sciences, Bethesda, Md.

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Antimicrobial Agents and Chemotherapy, July 2002, p. 2299-2302, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2299-2302.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

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