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Antimicrobial Agents and Chemotherapy, August 2002, p. 2409-2419, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2409-2419.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Methods for Data Mining from Large Multinational Surveillance Studies

James Poupard,* James Brown, Robert Gagnon, Michael J. Stanhope, and Chad Stewart

GlaxoSmithKline, Collegeville, Pennsylvania 19426-0989

Received 19 April 2001/ Returned for modification 27 January 2002/ Accepted 24 April 2002

Traditionally, large surveillance studies have been analyzed by the use of the MICs at which 90% of isolates tested are inhibited (MIC90s), MIC50s, frequency distributions, and percent susceptibility. In the past, these approaches have proved satisfactory for the monitoring of resistance. From these traditional uses, one can readily detect an increase in MICs for organism and drug combinations. Now that large surveillance studies have been conducted for a number of years and databases have grown to include a large number of datum points, new approaches to the extraction of useful information from these studies are needed. The present study proposes approaches, including the use of antibiotypes, principal components analysis, phylogenetics, and population genetic analysis, to the evaluation of data from large multinational surveillance studies. Application of these types of analyses can be used to describe genetic diversity, analyze changes in susceptibility patterns over time, and possibly, shed light on the origins and evolution of antimicrobial resistance. As global surveillance studies become more common and new questions concerning the evolution of resistance are raised, innovative approaches to analysis of the data will increase in importance.

* Corresponding author. Mailing address: Antimicrobial Profiling and Clinical Microbiology, GlaxoSmithKline, 1250 S. Collegeville Rd., Mail Code UP1340, Collegeville, PA 19426-0989. Phone: (610) 917-6284. Fax: (610) 917-4617. E-mail: James.A.Poupard{at}gsk.com.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2409-2419, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2409-2419.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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